Modeling Biology

Cell Biology Modeling Development

The fundamental problem of pattern formation for example, how to specify body axes, limbs, digits during development comes down to interpreting a common set of genetic instructions differently at different locations in space (Wolpert 1969). (See Figure 1.1 for an illustration). In all multicellular animals, this process is orchestrated by morphogens, molecules that are produced at discrete site...

Modeling Cancer Biology

Stochastic Modeling in Systems Biology

Many cellular behaviors are regulated by gene regulation networks, kinetics of which is one of the main subjects in the study of systems biology. Because of the low number molecules in these reacting systems, stochastic effects are significant. In recent years, stochasticity in modeling the kinetics of gene regulation networks have been drawing the attention of many researchers. This paper is a...

Spatial Statistical Modeling in Biology

Network modeling in systems biology

...........................................................................................................iv CHAPTER 1. INTRODUCTION ................................................................................... 1 1.1 Background ......................................................................................................... 1 1.2 Network Diagram...................................